{"id":223,"date":"2019-03-08T00:08:47","date_gmt":"2019-03-08T00:08:47","guid":{"rendered":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/?page_id=223"},"modified":"2019-05-13T16:56:49","modified_gmt":"2019-05-13T16:56:49","slug":"documentation","status":"publish","type":"page","link":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/documentation\/","title":{"rendered":"Bacterial Nucleoids"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"--awb-margin-top-small:10px;--awb-margin-right-small:0px;--awb-margin-bottom-small:10px;--awb-margin-left-small:0px;\"><h1 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\"><h3>Models of Bacterial Nucleoids<\/h3><\/h1><\/div><div class=\"fusion-text fusion-text-1\"><p>LatticeNucleoid is a collection of software for the rapid generation of bacterial nucleoid models that integrates experimental data from a variety of biophysical techniques and provides a starting point for simulation and hypothesis generation. The current method builds models of a circular bacterial genome with supercoiled plectonemes, packed within the small space of the bacterial cell. The method has been tested on for <i>Mycoplasma genitalium<\/i> and <i>Escherichia coli<\/i> nucleoids and is rapid enough to allow generation of multiple models when analyzing structure\/function relationships.<\/p>\n<p>The method is described in the paper:<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29338247\">&#8220;Lattice Models of Bacterial Nucleoids&#8221; DS Goodsell, L Autin &amp; AJ Olson, J. Phys. Chem. B, 122, 5441-5447 (2018).<\/a><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-223","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/pages\/223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/comments?post=223"}],"version-history":[{"count":18,"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/pages\/223\/revisions"}],"predecessor-version":[{"id":349,"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/pages\/223\/revisions\/349"}],"wp:attachment":[{"href":"https:\/\/ccsb.scripps.edu\/latticenucleoid\/wp-json\/wp\/v2\/media?parent=223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}