Models of Bacterial Nucleoids

LatticeNucleoid is a collection of software for the rapid generation of bacterial nucleoid models that integrates experimental data from a variety of biophysical techniques and provides a starting point for simulation and hypothesis generation. The current method builds models of a circular bacterial genome with supercoiled plectonemes, packed within the small space of the bacterial cell. The method has been tested on for Mycoplasma genitalium and Escherichia coli nucleoids and is rapid enough to allow generation of multiple models when analyzing structure/function relationships.

The method is described in the paper:

“Lattice Models of Bacterial Nucleoids” DS Goodsell, L Autin & AJ Olson, J. Phys. Chem. B, 122, 5441-5447 (2018).